Researchers address why kids are less susceptible to COVID-19
According to the study, receptor protein on the surfaces of specific lung cells spike after a particle containing coronavirus is inhaled into the lungs making the person more vulnerable.
Scientists in their research study have actually discovered why COVID-19 mainly impacts grownups and older people while kids are less prone to the virus.
According to an US group of researchers, including those from the Vanderbilt University Medical Center (VUMC), lower levels of receptor protein in kids protects them from the infection. The COVID-19 infection uses receptor protein as a medium to assault the epithelial cells in the lung stated the research study.
The Clinical Examination journal published the findings of the research.
” Our study offers a biologic reasoning for why especially babies and really young kids appear to be less most likely to either get infected or to have severe disease signs,” said Jennifer Sucre, a co-author of the research study from VUMC.
According to the research study, receptor protein on the surface areas of certain lung cells surge after a particle including coronavirus is breathed in into the lungs making the person more susceptible.
” Our research study has actually always focused on understanding lung advancement and how infant’s lungs vary from adult lungs in their vulnerability to injury,” Sucre stated.
” In this research study, we actually took the opposite approach, and were able to see how the establishing lung by its differences is secured from SARS-CoV-2 infection,” she further included.
A single-cell RNA-sequencing method was utilized by the researchers to spot the expression of genes in the lung of mice.
Bryce Schuler, another co-author of the research study, said that the gene for ACE2 – a receptor protein on the surfaces of specific lung cells – was revealed at low levels. “TMPRSS2 stood out as having a truly striking trajectory of increased expression during advancement,” said Schuler.
” What we found is that expression of (TMPRSS2) increases significantly with aging, and we see that at the level of the gene and at the level of the protein. We see a lot more TMPRSS2 in older people, in both people and mice,” Sucre included.
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